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Medisearch Clinical Trials

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St. Joseph, Mo. 64506

Urticaria  (itch & hives)
Clinical Trial: Celldex CDX0159-12NCB 18424-312
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Understanding Urticaria (Hives): Causes, Effects, and Impact

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What is Urticaria?

Urticaria, commonly known as hives, is a skin condition characterized by red, itchy, raised welts that appear suddenly. These welts can vary in size and shape and may merge to form larger patches. Urticaria can be acute, lasting for a few hours to a few weeks, or chronic, persisting for more than six weeks and recurring over months or years.

Although hives are not contagious or life-threatening, they can significantly impact a person’s quality of life, causing discomfort, stress, and emotional distress.

What Causes Urticaria?

Urticaria occurs when histamine and other immune system chemicals are released into the skin, triggering inflammation and itching. Common triggers include:

  • Allergic Reactions: Certain foods (shellfish, nuts, dairy, eggs), medications (antibiotics, NSAIDs), insect stings, and pollen can cause hives.

  • Environmental Factors: Extreme temperatures, sunlight, or water exposure can trigger a reaction in some individuals.

  • Physical Stimuli: Pressure on the skin, scratching, exercise, or vibrations can lead to the development of hives.

  • Infections: Viral or bacterial infections, including the common cold, sinus infections, and urinary tract infections, may provoke urticaria.

  • Autoimmune Disorders: In some cases, the immune system mistakenly attacks healthy cells, causing chronic hives.

  • Stress: Emotional stress and anxiety can worsen symptoms or trigger hives in some individuals.

Physical Effects of Urticaria

Urticaria can present as:

  • Raised, Red or Skin-Colored Welts: These welts may appear on any part of the body and change location within hours.

  • Itching or Burning Sensation: The affected areas can be extremely itchy and, in some cases, cause a burning or stinging sensation.

  • Swelling (Angioedema): In some cases, swelling occurs beneath the skin, affecting areas like the lips, eyes, and throat. Severe cases of angioedema can lead to breathing difficulties and require immediate medical attention.

  • Temporary Skin Changes: Hives can fade within hours or persist for days, but they usually leave no permanent marks.

Emotional and Psychological Effects of Urticaria

While urticaria is a physical condition, it can have a significant emotional and psychological impact, especially when symptoms are persistent or severe.

  • Discomfort and Disruption: The constant itching and burning sensation can interfere with daily activities, work, and sleep.

  • Self-Consciousness: Visible hives may cause embarrassment and self-esteem issues, leading individuals to avoid social situations.

  • Anxiety and Depression: Chronic urticaria can lead to emotional distress, frustration, and mental health concerns due to its unpredictable nature.

  • Sleep Disturbances: Nighttime itching can prevent restful sleep, leading to fatigue and difficulty concentrating.

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